The science of Amarasate

Amarasate works by triggering the "bitter brake" - a physiological mechanism that tells the brain to stop eating.

When specific cells in the small intestine - the area of the gut past the stomach – sense certain bitter compounds in food, a hormonal response is triggered that tells the brain to stop eating. This is a mechanism we have termed the "bitter brake".

The surface of the human gut contains a number of different cell types. Some of these cells sense what is in food as it is digested and absorbed, and produce signals that prepare the rest of the body to use the huge variety of compounds found in our food.

About one in 1000 cells on the surface of the gut is an enteroendocrine cell. Some of these enteroendocrine cells have bitter taste receptors that detect specific bitter compounds, such as those found in Amarasate®. Triggering these cells in the small intestine, particularly the duodenum (an area immediately after the stomach), produces signals that are known to modify eating behaviour.

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